Project Detail

A key feature of the biological organization in all organisms is the tendency of proteins that function in common pathways to physically associate via stable protein-protein interactions (PPI) to form larger macromolecular assemblies or complexes (sometimes known as molecular machines). These complexes are often linked together by extended networks of weaker, transient PPI, to form extended networks or neighbourhoods that integrate pathways mediating the major cellular processes..... (more information)