Bacterial Interactome Research
The set of interactions among genes and the proteins they encode, called the Interactome, provides valuable insight in the functional organization of biological systems, enabling the elucidation of how genes and proteins function in concert, and their roles in beneficial or harmful relationships with multi-cellular hosts.
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The Interactome can be represented at multiple levels, such as, the physical interactions forming protein complexes, epistatic interactions between functionally redundant genes, the biochemical reactions of enzymes in nutrient acquisition and homeostasis, and gene co-expression under different environmental conditions.
Through extensive collaboration, the Parkinson Lab deals with a vast amount of data produced by wide array of state-of-the-art methodologies that are applied to describing the Interactome of the model Gram-negative bacterium Escherichia coli. Given the complexity of this data we develop and employ a myriad of computational approaches to visualize, analyze and integrate the bacterial Interactome, providing unique large-scale pictures of the orchestrated inner-workings of a bacterium.